HFSA: Neprilysin Post-MI Fails to Reverse LV Remodeling

Sample size and study duration may be a factor in null outcome

Neprilysin inhibitors have vasodilatory, anti-hypertrophy, anti-fibrotic, and sympatholytic effects, all of which suggest that they could slow or prevent the left ventricular remodeling that may occur following myocardial infarction — remodeling that leads to heart failure.

That was the hypothesis that British Heart Fund researchers tested in a randomized trial comparing sacubitril/valsartan to valsartan alone in patients at high risk for heart failure following MI.

But Kieran Docherty, MD, of the British Heart Fund Research Centre at the University of Glasgow and Queen Elizabeth University Hospital in Glasgow, and colleagues found that “patients with asymptomatic left ventricular systolic dysfunction (and low NT-proBNP levels) following MI did not achieve a significant reverse remodeling effect with sacubitril/valsartan compared to valsartan.”

Docherty said he and his colleagues enrolled patients who were at least 3 months post-MI, had an LVEF of 40%

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Global Precision Medicine Market 2020-2030: Remodeling the One-Size-Fits-All Theory to Individually Tailored Therapy

The MarketWatch News Department was not involved in the creation of this content.

Dublin, Sep 30, 2020 (GLOBE NEWSWIRE via COMTEX) —
Dublin, Sept. 30, 2020 (GLOBE NEWSWIRE) — The “Global Precision Medicine Market: Focus on Ecosystem, Technology, Application, Country Data (21 Countries), and Competitive Landscape – Analysis and Forecast, 2020-2030” report has been added to ResearchAndMarkets.com’s offering.

Global Precision Medicine Market to Reach $278.61 Billion by 2030

Precision medicine refers to the medicine developed as per an individual’s genetic profile. It provides guidance regarding the prevention, diagnosis, and treatment of diseases. The segmentation of the population is done depending on the genome structure of the individuals and their compatibility with a specific drug molecule.

In the precision medicine market, the application of molecular biology is to study the cause of a patient’s disease at the molecular level, so that target-based therapies or individualized therapies can be applied to cure

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Annual NARI Home & Remodeling Show starts Oct. 16 at State Fair Park

The annual NARI Home & Remodeling Show will be slightly smaller this year as the coronavirus pandemic keeps more people at home and interested in making improvements. 



a person standing in front of a building: Trent Kosik from Window Select in Menomonee Falls paints the doors of a 'She Shed' that will be on display at the Nari Milwaukee Spring Home Improvement Show at Wisconsin State Fair Park this weekend.


© Angela Peterson/Milwaukee Journal Sentinel
Trent Kosik from Window Select in Menomonee Falls paints the doors of a ‘She Shed’ that will be on display at the Nari Milwaukee Spring Home Improvement Show at Wisconsin State Fair Park this weekend.

NARI Milwaukee is hosting its home and remodeling show Oct. 16-18 at State Fair Park. 

Around 70 NARI Milwaukee members will host exhibit booths. Last year, more than 100 members staffed exhibit booths. The home and remodeling show has exhibitors for all types of remodeling and home improvement products and services. 

Get daily updates on the Packers during the season.

“We’re excited to connect homeowners who are eager to get their home improvements underway with local contractors. By hosting a safe and

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Condo Life: Remodeling adds personal touch for condo living

Published

Remodeling your home can either be a smooth transition or a rocky one, but knowing the specifics of remodeling a condominium is incredibly important, as homeowners have different hurdles to face.

In the 2018 report by Livable.com, 10 Things You Absolutely Need to Know Before Renovating a Condo, the top item on the list is to consult your condo board well in advance. The reason for this is every condo building is different regarding rules and regulations about construction in the building. The condo HOA or board will then inform you of the basic guidelines for what can and can’t be done for renovations, it stated.


Addressed in the report as well are things to be aware of, such as newly constructed buildings may not yet have rules in place for renovations, and you have to be

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The Builders Home & Remodeling Show is underway

With 70,000 square feet available, this show offers plenty of space to stay socially distant.

ST. LOUIS — The Builders Home & Remodeling Show is underway. Doors opened at 10 a.m. today at the St. Charles Convention Center.

This is a great place to check out if you’re planning some fall and winter projects this year.

With 70,000 square feet available, this show offers plenty of space to stay socially distant.

The Builders Home & Remodeling Show runs from September 25 – 27, 2020. The hours for Friday and Saturday are 10 a.m. to 7 p.m., and the hours for Sunday are 10 a.m. to 5 p.m.

It takes place at the St. Charles Convention Center, which is located at One Convention Center Plaza in Saint Charles, Mo. For more information, call (314) 994-7700 or visit stlhomeshow.com/HomeRemodeling.

THIS ARTICLE INVOLVES COMMERCIAL CONTENT. THE PRODUCTS AND SERVICES FEATURED APPEAR AS PAID

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123 Remodeling Earns Better Business Bureau Accreditation – Press Release

Chicago, IL, United States – Becoming an Accredited Business with the Better Business Bureau is an honor not accorded to all businesses; because not all companies meet eligibility standards. 123 Remodeling is pleased to announce today that it has met all BBB standards and is now an Accredited Business.

“Accreditation in the BBB is by invitation only,” says Steve J. Bernas, president & CEO of the Better Business Bureau serving Chicago and Northern Illinois. “And only those businesses that meet our high standards and pass the review process are approved by our Board of Directors.”

As with all businesses that are Accredited by the BBB, 123 Remodeling has committed to the BBB Code of Business Practices.  The Code is a comprehensive set of policies, procedures, and best practices for treating consumers. These standards call for building trust, embodying integrity, advertising honestly, and being truthful. Bernas adds, “To maintain their Accreditation

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TL1A and its receptor could reduce fibrosis and tissue remodeling in patients with severe lung disease

Your lungs and airways need to be stretchy, sort of like balloons. Take a big breath, and they’ll open right up.

Damaged lungs can’t open properly. Patients with asthma, idiopathic pulmonary fibrosis and systemic sclerosis suffer from fibrosis and tissue remodeling, where a build-up of tissue and immune cells, and proteins that form a glue-like substance, keep the airways from expanding. As fibrosis gets worse, taking a breath feels like blowing up a balloon filled with concrete.

In a new study, researchers at La Jolla Institute for Immunology (LJI) report that a protein called TL1A drives fibrosis in several mouse models, triggering tissue remodeling, and making it harder for lungs and airways to function normally.

“Our new study suggests that TL1A and its receptor on cells could be targets for therapeutics aimed at reducing fibrosis and tissue remodeling in patients with severe

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Wagner Metal Roofing & Remodeling committed to Safety & Customer Service – Press Release

“The Team of Wagner Metal Roofing & Remodeling during their weekly safety briefing & training and discussing upcoming jobs.”

Wagner Metals Roofing and Remodeling is a full-service construction company centrally located in Oakwood, OH. Brett Wagner created the company over 10-years ago to service the community with high-quality, ethical construction services. Wagner Metals Roofing and Remodeling just began with Brett Wagner and some friends working together in a shop. Since creating the business, Wagner and his team have flourished in numbers, services, and experience.

Northwest Ohio’s Leading Metal Roofing Company

Wagner Metals Roofing and Remodeling is rated the leading metal roofing company with the number one metal roofing contractors in Ohio. Metal roofing contractors employed at the construction company are certified by the Metal Construction Association to ensure premium performance. Although this construction company specializes in metal roofing, they offer various other services. From steel roofing and siding services to

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Scientists track down a protein that may add to lung damage in asthma and related diseases

A step toward helping patients breathe deeply
A protein called TL1A drives fibrosis in several mouse models, making it harder for lungs and airways to function normally. Credit: La Jolla Institute for Immunology

Your lungs and airways need to be stretchy, sort of like balloons. Take a big breath, and they’ll open right up.

Damaged lungs can’t open properly. Patients with asthma, idiopathic pulmonary fibrosis and systemic sclerosis suffer from fibrosis and tissue remodeling, where a build-up of tissue and immune cells, and proteins that form a glue-like substance, keep the airways from expanding. As fibrosis gets worse, taking a breath feels like blowing up a balloon filled with concrete.

In a new study, researchers at La Jolla Institute for Immunology (LJI) report that a protein called TL1A drives fibrosis in several mouse models, triggering tissue remodeling, and making it harder for lungs and airways to function normally.

“Our new study suggests that TL1A and its receptor

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A step toward helping patients breathe deeply

IMAGE

IMAGE: A protein called TL1A drives fibrosis in several mouse models, making it harder for lungs and airways to function normally.
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Credit: La Jolla Institute for Immunology

LA JOLLA–Your lungs and airways need to be stretchy, sort of like balloons. Take a big breath, and they’ll open right up.

Damaged lungs can’t open properly. Patients with asthma, idiopathic pulmonary fibrosis and systemic sclerosis suffer from fibrosis and tissue remodeling, where a build-up of tissue and immune cells, and proteins that form a glue-like substance, keep the airways from expanding. As fibrosis gets worse, taking a breath feels like blowing up a balloon filled with concrete.

In a new study, researchers at La Jolla Institute for Immunology (LJI) report that a protein called TL1A drives fibrosis in several mouse models, triggering tissue remodeling, and making it harder for lungs and airways to function normally.

“Our new study suggests that

Read More