Sample size and study duration may be a factor in null outcome
Neprilysin inhibitors have vasodilatory, anti-hypertrophy, anti-fibrotic, and sympatholytic effects, all of which suggest that they could slow or prevent the left ventricular remodeling that may occur following myocardial infarction — remodeling that leads to heart failure.
That was the hypothesis that British Heart Fund researchers tested in a randomized trial comparing sacubitril/valsartan to valsartan alone in patients at high risk for heart failure following MI.
But Kieran Docherty, MD, of the British Heart Fund Research Centre at the University of Glasgow and Queen Elizabeth University Hospital in Glasgow, and colleagues found that “patients with asymptomatic left ventricular systolic dysfunction (and low NT-proBNP levels) following MI did not achieve a significant reverse remodeling effect with sacubitril/valsartan compared to valsartan.”
Docherty said he and his colleagues enrolled patients who were at least 3 months post-MI, had an LVEF of 40%